- Sarita Choudhury (2 movies)
- Scoot McNairy (2 movies)
- Sean Bridgers (2 movies)
- Sean O'Bryan (2 movies)
- Sebastian Koch (2 movies)
- Sebastian Maniscalco (2 movies)
- Sergei Polunin (2 movies)
- Sergej Onopko (2 movies)
- Shane Carruth (2 movies)
- Shane Salter (2 movies)
- Sharlto Copley (2 movies)
- Shawn Campbell (2 movies)
- Solomon Taiwo Justified (2 movies)
- Stafford Douglas (2 movies)
- Stan Lee (2 movies)
- Stellan Skarsgård (2 movies)
- Stephen Fry (2 movies)
- Stephen Kunken (2 movies)
- Stephen Lang (2 movies)
- Stephen Root (2 movies)
- Steve Carell (2 movies)
- Steven Yeun (2 movies)
- Suehyla El-Attar (2 movies)
- Susie Porter (2 movies)
- Sylvester Stallone (2 movies)
- Sam Claflin (3 movies)
- Sarah Paulson (3 movies)
- Scarlett Johansson (3 movies)
- Shea Whigham (3 movies)
- Sofia Boutella (3 movies)
- Stanley Tucci (3 movies)
- Sam Spruell (4 movies)
- Sebastian Stan (4 movies)
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