We never find out why or how, but the world’s population has been wiped out entirely and turned the planet into a poisonous wasteland. Apparently, some of humanity had anticipated this and created a a facility that houses thousands of embryos to repopulate earth with. This facility is run by an Articial Intelligence, which presents itself as a robot called Mother (voiced by Rose Byrne). She raises a single embryo, Daughter (Clara Rugaard), to adulthood, teaching and testing her along the way.
Annie (Rose Byrne) lives with her boyfriend Duncan (Chris O’Dowd) and they find themselves in a deep rut, something she sort of know but lacks the chutzpah to do anything about, and something he seems too self-obsessed to realise. Actually, Duncan is obsessed with someone else: Tucker Crowe, an obscure American rocker who disappeared in the middle of a gig sometime in the 90s.