We never find out why or how, but the world’s population has been wiped out entirely and turned the planet into a poisonous wasteland. Apparently, some of humanity had anticipated this and created a a facility that houses thousands of embryos to repopulate earth with. This facility is run by an Articial Intelligence, which presents itself as a robot called Mother (voiced by Rose Byrne). She raises a single embryo, Daughter (Clara Rugaard), to adulthood, teaching and testing her along the way.